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    Talking about the production principle of tablet press

    Release time: August 21, 2020 number of hits: 15 times
       Tablet machine It is mainly used for the research of tablet technology in pharmaceutical industry. It is an automatic continuous production equipment for pressing granular materials into round and irregular shapes with diameter no more than 13mm and with characters, symbols and graphics. Some pharmaceutical tablet presses have burr and dust during tablet pressing, so they should be equipped with screening machine to remove dust at the same time (more than twice), which must meet GMP standards.
     
    Let me tell you about its production principle:
     
    (1) dose control. Various tablets have different dose requirements, and large dose adjustment is achieved by selecting different punch diameters, such as 6 mm, 8 mm, 11.5 mm, 12 mm punches. After the size of the die is selected, the micro dose adjustment is to adjust the depth of the punch into the middle die hole, so as to change the actual length of the middle die hole after the back cover, and adjust the filling volume of the drug in the die hole. Therefore, the tablet press should have a mechanism to adjust the original position of the punch in the die hole to meet the requirements of dose adjustment. Because of the difference of specific volume in the preparation of different batches of powder, this regulation function is very necessary.
     
    In the dose control, the action principle of the feeder also has a considerable influence. For example, when the granular drug is free to roll into the hole of the middle mold by its own weight, the filling situation is relatively loose. If multiple forced entry is used, more drugs will be filled into the mold hole, and the filling situation will be more dense.
     
    (2) control of tablet thickness and compaction degree. The dosage of the drug is determined according to the prescription and pharmacopoeia and cannot be changed. In order to meet the time limit of storage, transportation, preservation and disintegration, a certain dose of pressure is also required during tablet compression, which will also affect the actual thickness and appearance of the tablet. It is necessary to adjust the pressure during tablet pressing. This is achieved by adjusting the downward amount of punch in the die hole. Some tablet presses not only have up and down action in the process of tablet pressing, but also can have downward movement, which completes the tablet pressing process by the relative movement of up and down. However, the pressure regulation is mostly realized by adjusting the mechanism of up and down stroke.
     
    The working process of the press can be divided into the following steps:
     
    1. The punch part of down punching (its working position is upward) extends from the lower end of the middle die hole into the middle die hole to seal the bottom of the middle die hole;
     
    2. Filling medicine into the hole of the middle mould with a feeder;
     
    3. The punch part of the upper punch (its working position is downward) falls into the middle die hole from the upper end of the middle die hole, and goes down a certain stroke to press the powder into pieces;
     
    Lift out the upper hole. The tablet is pushed out of the middle die hole by down punching and rising to complete a tablet pressing process;
     
    5. Go down to the original position and prepare for the next filling.