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    Production method of duck beak suppository by hot melt molding

    Release time: March 6, 2020 number of hits: 740
    Suppository mold is mainly used to make suppository molding mold. Suppositories can be divided into rectal suppository and Niao suppository, such as Niao suppository and dental suppository, among which hip suppository is more commonly used. Among them, duck's beak suppository mold is characterized by less investment, quick effect and simple operation. The material is aluminum alloy.
       Duck beak suppository mould The more commonly used method is hot melting.
    The technological process of preparation of suppository by hot melt method is as follows: melting matrix, adding medicine (mixing), injection molding, cooling, scraping and taking out.
    First clean and dry the plug mould, and apply a little lubricant to the inside of the mould. Then, according to the nature of the drug, add the drug in different ways, mix it evenly, pour it into the suppository mold until it overflows the mold mouth, cool it down, and after the complete solidification, cut off the overflow part with a knife, open the model, and push out the suppository. This method is suitable for the preparation of suppository with fat matrix and water-soluble matrix.
    (1) the method of adding suppository drugs
    1. Insoluble drugs should be crushed into fine powder and then mixed with matrix;
    Oil soluble drugs can be directly dissolved in the melted oily matrix;
    (3) water soluble drugs can be directly mixed with the melted water-soluble matrix, or absorbed with appropriate amount of lanolin and mixed with oily matrix.
    (2) lubricant:
    The suppository mould hole should be lubricated with lubricant to facilitate the removal of suppository after condensation. There are two common types
    (1) the suppository of oily matrix is usually made of soap, 1 part of glycerol and 5 parts of 90% ethanol.
    (2) the suppositories with water-soluble or hydrophilic matrix are usually oily lubricants, such as liquid paraffin, vegetable oil, etc.
    In addition, there are kneading, cold pressing and so on
    Cold pressing method: this method uses instruments to press suppositories, which is suitable for mass production of fat matrix suppositories. This method is similar to the kneading method. The medicine is put into a suitable container, and the same amount of matrix is added to grind it evenly, and then the remaining matrix is added to grind it into agglomerates. After cooling, it is made into file or granule, and then it is installed in the pipe of the suppository making machine and pressed into a certain shape through the model. In order to ensure the required amount of extrusion, it is often necessary to add 10% - 20% more raw materials, and the pressure must be the same.
    Add a small amount of powder to make it soft, such as a small amount of powder. If necessary, appropriate amount of vegetable oil or lanolin can be added to increase plasticity. Then it is placed on the porcelain plate, kneaded with paper by hand, turned into a cylinder under pressure, and then divided into several equal parts according to the required amount, and kneaded into appropriate shape.