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    Tablet coating technology and common problems

    2014-12 times: 6509 times

    Problems and Countermeasures of tablet coating technology
      
    Sticking: it is mainly due to the fast spray rate, which violates the principle of solvent evaporation balance and causes the tablets to adhere to each other. In this case, the spray amount of coating liquid should be reduced, the hot air temperature should be increased, and the speed of coating pot of coating machine should be accelerated.
      
    The appearance of "orange peel" film: it is mainly due to improper drying and low spray pressure of coating liquid, which causes uneven concentration of spray droplets, resulting in ripple of coating film. In this case, the evaporation rate should be controlled immediately and the spray pressure should be increased.
      
    The "frost spray" of the film is caused by the high humidity of the hot air, the long spraying distance and the poor atomization effect. At this time, it is necessary to reduce the temperature, shorten the spray range and improve the atomization effect.
      
    Color difference between tablets: this situation is caused by uneven spraying fan, excessive coating liquid and solid content or slow speed of coating machine. At this time, the angle of spray gun should be adjusted, the solid content of coating liquid should be reduced, and the rotation speed of coating machine should be properly increased.
      
    There are pinholes on the surface of the coating film: This is caused by excessive air involved in the preparation of the coating solution. Therefore, too much air should be avoided when mixing liquid.
      
    "Bridge": refers to the film on the lettering piece causing the mark to be blurred. The solution is to slow down the coating spraying speed, reduce the drying temperature, and pay attention to control the hot air temperature.
      
    The appearance of color spots: this situation is due to the coating solution when mixing uneven or solid characteristics caused by insufficient fineness. The solution is: the coating solution should be fully stirred evenly.
      
    Cracks, cracks, spalling or abrasion of the coating film on the surface or edge of the tablet: if the coating liquid and solid content is not properly selected, the coating machine speed is too fast, and the spray volume is too small, the appropriate coating liquid-solid content should be selected, and the rotation speed and spraying amount should be adjusted appropriately; if the hardness of the core is too poor, the formulation and process of the core should be improved.